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TIRZEPATIDE for Weight Loss

Tirzepatide is a novel dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist that has shown exceptional effectiveness in promoting weight loss. It works through a unique mechanism that combines the benefits of both GIP and GLP-1 hormones to significantly reduce body weight.

Mechanism of Action: Tirzepatide works by:

  • Enhancing insulin secretion in response to meals

  • Suppressing glucagon release, which reduces hepatic glucose production

  • Slowing gastric emptying, leading to prolonged satiety and reduced appetite

  • Improving insulin sensitivity, which enhances overall metabolic health

 

These combined effects help reduce calorie intake and promote significant weight loss.

Tirzepatide’s efficacy in weight loss has been demonstrated in several clinical trials, particularly the SURPASS trials:

  1. SURPASS-2:

    • Participants: Individuals with type 2 diabetes and a BMI ≥30 or ≥27 with weight-related comorbidities.

    • Results: Participants receiving Tirzepatide achieved up to 15% weight loss over 72 weeks, compared to those on Semaglutide, who had slightly lower weight reduction.

  2. SURPASS-3 and 5:

    • Participants: Individuals with type 2 diabetes.

    • Results: These trials confirmed Tirzepatide's superior weight loss effects, with participants losing up to 20% of their body weight over 72 weeks.

  3. SURPASS-1:

    • Participants: Individuals without diabetes but with obesity or overweight with weight-related comorbidities.

    • Results: Tirzepatide led to significant weight reduction, demonstrating its effectiveness even in non-diabetic populations.

 

Safety Profile: Tirzepatide is generally well-tolerated, with common side effects including gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation. These symptoms are usually mild to moderate and tend to decrease over time. Serious but rare side effects may include pancreatitis, gallbladder issues, and kidney problems.

 

Administration: Tirzepatide is administered as a subcutaneous injection once a week. It can be injected into the abdomen, thigh, or upper arm. It is important to follow the healthcare provider's instructions on the proper injection technique and schedule.

 

Tirzepatide is a highly effective medication for weight management, supported by substantial clinical evidence demonstrating significant and sustained weight loss. Its dual action on GIP and GLP-1 receptors offers a comprehensive approach to weight reduction, making it a promising option for individuals struggling with obesity or overweight with weight-related comorbidities. Discuss with your healthcare provider to determine if Tirzepatide is right for you and to understand the potential risks and benefits.

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FAQ

What is the difference between Semaglutide and Tirzepatide? Semaglutide, a GLP-1 receptor agonist, promotes weight loss by increasing insulin secretion, reducing appetite, and slowing gastric emptying, resulting in effective appetite control and calorie reduction. Tirzepatide, with its dual action on GIP and GLP-1 receptors, not only enhances these effects but also significantly improves insulin sensitivity. This dual mechanism offers a more robust approach to weight loss, potentially leading to greater and more sustained weight reduction compared to Semaglutide.

Who is eligible for these medications? Adults with a BMI of 30 kg/m² or greater (obesity) Adults with a BMI of 27 kg/m² or greater (overweight) with at least one weight-related comorbidity (e.g., hypertension, type 2 diabetes, dyslipidemia)

What are potential side effects of these medications? Common side effects include nausea, vomiting, diarrhea, and constipation, while less common effects are abdominal pain, indigestion, and fatigue. Serious side effects, though rare, may include pancreatitis, gallbladder issues such as gallstones, kidney problems, and allergic reactions. Discuss these potential side effects with your healthcare provider before starting treatment.

How much weight can I expect to lose? For Semaglutide, the STEP trials demonstrated an average weight loss of around 15% of body weight over 68 weeks in adults with obesity or overweight with weight-related conditions. Participants also saw improvements in cardiovascular health markers and glycemic control. For Tirzepatide, the SURPASS trials indicated even greater weight loss, with participants losing up to 20% of their body weight over 72 weeks. Additionally, Tirzepatide showed improvements in insulin sensitivity, lipid profiles, and other metabolic health markers. These results highlight the potential for substantial weight reduction and overall health improvement with both medications. It is important to discuss with your healthcare provider to determine the best option for your individual needs.

How are these medications taken? Both Semaglutide and Tirzepatide are taken as subcutaneous injections, administered once a week. These injections can be self-administered in the abdomen, thigh, or upper arm. It is important to follow your healthcare provider's instructions on the proper injection technique and schedule.

What are compounded medications? We offer compounded Semaglutide and Tirzepatide, featuring the same active ingredients as the commercial products Wegovy® and Mounjaro®/Zepbound™, respectively. Our unique formulations also include L-carnitine, which may assist in fat burning and enhance energy levels. Disclaimer: Compounded medications are not FDA-approved and should be discussed with your healthcare provider to understand the specific risks and benefits. While compounded in licensed pharmacies, these medications may not have the same safety and efficacy profiles as commercially available drugs.

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